Say Goodbye to Dark Circles: Why Polynucleotides Are the Ultimate Under Eye Treatment in Birmingham

Are you tired of looking tired? If you’ve been battling under eye dark circles, you're not alone — and there’s a powerful new treatment making waves in the world of aesthetic medicine: polynucleotides. At My Cosmetic Doctor, a leading cosmetic clinic based in Harborne, Birmingham, we’re proud to offer this revolutionary solution to help you look brighter, fresher, and more awake — without the downtime of traditional options like tear trough filler.

In this blog, we’ll explain:

• What causes under eye dark circles
  
• Why polynucleotides are changing the game
  
• How they compare to tear trough filler
  
• Why this treatment could be the best option for your unique concerns
  

What Are Polynucleotides?

Polynucleotides are a revolutionary injectable treatment derived from highly purified fragments of DNA, typically sourced from salmon or trout. But don’t worry – these are treated and sterilised to ensure complete safety and biocompatibility.

Rather than simply adding volume like traditional fillers, polynucleotides stimulate your body’s own regenerative processes, including collagen and elastin production, hydration, and improved tissue quality. Think of them as "cell whisperers," encouraging your skin to repair, renew, and regenerate from within.

Why We're Using the PLINEST Range by Dermafocus

At My Cosmetic Doctor, we only choose clinically proven, high-performing treatments for our patients. That’s why we’re offering PLINEST – the industry-leading polynucleotide products by Dermafocus.

Here’s why this range stands out:

• Winner of Injectable Product of the Year at the Aesthetics Awards 2025
  
• Backed by decades of scientific research and use in medical and aesthetic settings
  
• Advanced tissue repair properties, making it ideal for sensitive and delicate areas
  
• High purity and excellent safety profile
  

This is not just another trend – it’s a next-generation injectable that can truly transform the quality and health of your skin.

What Causes Dark Circles Under the Eyes?

Before exploring treatments, it's important to understand the common causes of under eye pigmentation and hollowness. Dark circles can result from a combination of:

• Genetics – Many people are simply predisposed to darker pigmentation or thinner skin under the eyes.
  
• Lack of Sleep & Fatigue – Poor sleep can cause the skin to appear paler, making underlying blood vessels more visible.
  
• Ageing & Volume Loss – As we age, we lose collagen and fat in the tear trough area, which can create hollows and shadows.
  
• Poor Circulation – Stagnant blood flow can lead to a bluish or purple tint under the eyes.
  
• Hyperpigmentation – Especially in darker skin types, increased melanin production can cause noticeable dark patches.
  
• Lifestyle Factors – Smoking, sun exposure, dehydration, and diet all play a role.
  

Because dark circles have multiple causes, treating them effectively requires more than a one-size-fits-all approach.

Enter Polynucleotides: A Regenerative Solution for Brighter Eyes

Polynucleotide under eye treatment is fast becoming one of the most sought-after non-surgical solutions for dark circles in the UK. Unlike traditional fillers, which simply add volume, polynucleotides actually work to regenerate and heal the skin at a cellular level.

Here's the science:

• Stimulate Cellular Regeneration
  

Polynucleotides are highly purified DNA fragments (usually derived from salmon or trout) that act as bio-stimulators. When injected into the skin, they promote fibroblast activity — the cells responsible for producing collagen, elastin, and extracellular matrix — all of which are crucial for firm, smooth under-eye skin.

• Improve Microcirculation
  

One key issue in dark under-eye circles is poor blood flow and visible capillaries. Polynucleotides enhance angiogenesis (the formation of new blood vessels), which improves microvascular circulation. Better blood flow helps reduce the blue/purple hue caused by deoxygenated blood pooling beneath thin skin.

• Reduce Inflammation & Oxidative Stress
  

Polynucleotides have anti-inflammatory and antioxidant properties. They modulate cytokine activity, reducing chronic low-level inflammation in the skin — a key contributor to pigmentation and ageing. This makes them especially beneficial for patients with sensitive or post-inflammatory hyperpigmentation (PIH)-prone skin.

• Hydrate & Improve Skin Density
  

They increase skin hydration by attracting water molecules, similar to hyaluronic acid, but with the added benefit of stimulating tissue repair. This plumps and thickens the thin under-eye skin, making dark shadows and visible vessels less prominent.

• Target Hyperpigmentation & Skin Tone Irregularities
  

By encouraging healthy cell turnover and reducing oxidative damage, polynucleotides help fade melanin deposits and improve uneven pigmentation, particularly in darker skin types where under-eye hyperpigmentation is more common.

• Safe Collagen Boost Without Volume
  

Unlike tear trough fillers, which can risk overfilling or creating puffiness if not perfectly placed, polynucleotides do not add volume. Instead, they work gradually to boost skin quality, tone, and texture — a more natural, regenerative approach to under-eye rejuvenation.

Polynucleotides vs Tear Trough Filler: What's the Difference?

If you’ve researched under eye treatments, you’ve likely come across tear trough filler, typically made from hyaluronic acid. While this can be effective in the right candidates, it only addresses one issue: volume loss or under eye hollowness.

However, most patients suffer from more than just hollow eyes — they have pigmentation, thin crepey skin, or visible blood vessels, where filler can actually make the issue worse.

Why Polynucleotides Are Often Better:

• Targets More Than One Concern – Reduces discolouration, improves hydration, and firms the skin
  
• No Risk of Tyndall Effect – Unlike fillers, polynucleotides won’t create a blue tint under the skin
  
• Safe for Most Skin Types – Especially effective for darker skin tones prone to hyperpigmentation
  
• Builds Natural Results Over Time – With a course of treatments, you’ll see ongoing improvement in skin quality
  

At My Cosmetic Doctor, we often recommend polynucleotide eye treatments for patients who have previously been told they are “not suitable” for tear trough filler, or who want a more natural and regenerative approach.

What to Expect from Your Under Eye Polynucleotide Treatment in Harborne

At our clinic in Harborne, Birmingham, you’ll start with a comprehensive consultation with one of our experienced medical professionals. We’ll assess your under eye concerns, skin quality, and goals, then recommend a tailored treatment plan.

Treatment involves:

• A series of small injections under the eyes (usually 3–4 sessions spaced 3-4 weeks apart)
  
• Minimal downtime – slight swelling or redness may occur but typically resolves in 24–48 hours
  
• Results that build over time, improving with each session
  

Most patients begin to see visible improvement in skin brightness, firmness, and tone within a few weeks.

Why Choose My Cosmetic Doctor in Birmingham?

At My Cosmetic Doctor, we specialise in advanced non-surgical treatments using the latest in aesthetic medicine to help you feel confident in your skin. We’ve helped hundreds of patients across Birmingham, Edgbaston, Harborne, and the West Midlands transform their under eye area with natural, regenerative treatments.

We offer:

• Expert, medically-led consultations
  
• Safe and clinically-proven products
  
• Personalised treatment plans tailored to your concerns
  
• Award winning clinic- most trusted doctor led aesthetics clinic 2024 & 2025
  

💬 Dr. Kaur says:

"I’m so excited to introduce polynucleotide treatments to my patients. So many people come to me thinking they need tear trough filler, but often their main concern is actually dark circles or crepey skin — and in those cases, filler simply won’t help.

I also see patients who want to address their under-eye concerns but feel nervous about dermal filler — maybe they’ve heard horror stories, had a bad experience in the past, or needed their filler dissolved.

That’s why I took my time to research and observe what was available on the market. I wanted to make sure I was offering a treatment that’s not only effective, but safe, regenerative, works with your own body and genuinely delivers natural-looking results. For so many people, polynucleotides are exactly that."

Ready to glow from within?

Book your consultation at My Cosmetic Doctor today and discover how polynucleotides can transform your skin.

My Cosmetic Doctor | Harborne, Birmingham 
Specialists in subtle, natural aesthetics that work with your lifestyle.
 Let’s plan your best skin / face journey yet.

Contact our clinic to learn more about treatments we have on offer and schedule your consultation.

Our cosmetic doctors in Harborne, Birmingham, also take great pride prioritising continuity of care and are dedicated to delivering natural-looking results. Schedule a consultation with our clinic and experience the expertise and personalised care that sets us apart. 

References

Kim, H.J., Lee, H.J., Kim, J.H. and Lee, S.H., 2021. The efficacy of polynucleotides in skin rejuvenation: a comprehensive review. Journal of Cosmetic Dermatology, 20(8), pp.2473–2480.

Mazzalupi, G., Di Stefano, M.A., Bottino, D. and Serri, M., 2023. Polynucleotides in aesthetic medicine: evidence-based applications and patient satisfaction. Clinical, Cosmetic and Investigational Dermatology, 16, pp.231–240